Low-dose Radiation Effects and Intracellular Signaling Pathways
نویسندگان
چکیده
منابع مشابه
Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects.
A rapidly growing body of experimental evidence indicates that ionizing radiation induces biological effects in non-irradiated bystander cells that have received signals from adjacent or distant irradiated cells. This phenomenon, which has been termed the ionizing radiation-induced bystander effect, challenges the long-standing paradigm that radiation traversal through the nucleus of a cell is ...
متن کاملEffects of Low-Dose Ionising Radiation
Recent years there have been a number of discussions about the magnitude of the health risks resulting from the exposure to low levels of ionising radiation mainly within the American Health Physics Society, the French Academy of Sciences and the Canadian Radiation Protection Association. Essentially, the debate has centred on the question of linearity, i.e., whether to assume that the probabil...
متن کاملRadiation dose-rate effects, endogenous DNA damage, and signaling resonance.
We previously concluded, from our analysis of the published data of other investigators, that the yield of germ-line and somatic mutations after exposure to ionizing radiation is parabolically related to the logarithm of the dose-rate at which a given dose is administered. Here we show that other data reveal a similarly parabolic relationship for other ionizing radiation-associated phenomena, n...
متن کاملEndothelial activation: intracellular signaling pathways
Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the ex...
متن کاملScientific Risk Estimation on Health Effects of Low Dose and Low Dose-Rate Radiation - An Overview
Estimation of the scientific risks of high dose radiation has been successfully quantified by many studies using several different approaches. However, the risk for low and low dose-rate radiation is obscure because of a lack of evidence. This risk is currently estimated by extrapolating the radiation response at high doses into low dose ranges for practical purposes. Recent challenges to exami...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2006
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.126.859